Hemoglobin Oxygen Therapeutics LLC

Hemoglobin Oxygen Therapeutics LLC Announce Updated Results From The Netherlands Leading Liver Transplant Hospital

February 13, 2019

Pilot study shows ten donor livers previously rejected for transplant, salvaged with new machine perfusion technology using Company’s lead product, Hemopure®.

To date, results show 100 percent transplant and survival rates for all patients.

SOUDERTON, PA and GRONINGEN, The Netherlands. February 13 2019 —  Hemoglobin Oxygen Therapeutics LLC (HbO2 Therapeutics), a biopharmaceutical company specializing in oxygen therapeutics, today announced results from a pilot study on liver transplants conducted at the Netherlands largest transplantation center, the University Medical Center in Groningen (UMCG) under the direction of the lead investigator Professor Robert Porte, Head of Hepatobiliary Surgery and Liver Transplantation.

The study involved donor livers that were deemed unsuitable for regular transplantation. These organs were subjected to an innovative machine perfusion technology (a simulation of how the liver works in the body) using Hemopure, a novel synthetic oxygen solution that increases the oxygen-carrying capacity of blood. Given the solution’s ability to safely transport oxygen from much colder temperatures to body heat, initially rejected livers appear more likely to respond positively, becoming suitable for transplantation.

The results showed that 16 livers that were initially rejected by all transplant centers in The Netherlands, including UMCG, underwent machine perfusion to assess the organ’s viability at 37°C. Following viability testing including the ability to produce bile, ten donor livers were successfully reconditioned using Hemopure solution. A further benefit of applying this solution included the avoidance of any blood products during the perfusion process. HbO2 Therapeutics is pleased to announce 100% transplant and survival rates in the study including those patients receiving “refurbished” livers treated with Hemopure.

“We are thrilled to be collaborating with UMCG given that this is the first of its kind study with important variables tested in real time including individual liver differences, overall liver viability, and Hemopure perfusion,” said Zafiris Zafirelis, CEO of HbO2 Therapeutics. “The United Network for Organ Sharing (UNOS) estimates that over 13,700 people are currently waiting for a liver transplant nationwide, yet only about 8,250 transplants performed in 2018. Given the significant need to increase donor transplants, the key takeaway from this pilot study indicates that discarded donor livers could be refurbished with the help of Hemopure.”


More news
June 3, 2019
Hemoglobin Oxygen Therapeutics LLC Announces Multiple Presentations Using Hemopure® in Donor Livers Previously Rejected for Transplant.

The study represents the first ever-clinical application of Hemopure globally for ex situ warm machine perfusion of human donor livers. All 11 patients remain alive from six to 20 months post surgery. Oral presentations conducted at two prestigious conferences; findings have been submitted to an international peer review journal. SOUDERTON, Pa. and GRONINGEN, Netherlands, June…

April 18, 2019
Hemopure Plays A Pivotal Role in A Pioneering Study Published in Nature

Researchers from Yale School of Medicine Demonstrated Restored Cellular Functions In Pig Brains After Death Using Hemopure. Hemopure May Become a Novel, Broadly Applicable and Easy-to-Handle Perfusion Solution For Multiple Organs. SOUDERTON, Pa., April 18, 2019 /PRNewswire/ — Hemoglobin Oxygen Therapeutics LLC (HbO2 Therapeutics), a world leader in oxygen-carrying solutions, today announces pioneering research conducted…